KMID : 0869220150190020097
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Journal of Korean Geriatric Psychiatry 2015 Volume.19 No. 2 p.97 ~ p.100
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Reduced Cortical Thickness in Patients with Late Life Depression without Cerebral Vascular Disease
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Lee Kang-Youn
Lee Young-Min Park Je-Min Lee Byung-Dae Moon Eun-Soo Jeong Hee-Jeong Chung Young-In Kim Ji-Hoon
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Abstract
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Objective£ºThe aim of this study is to compare cortical thickness in late life major depression patients without cerebral vascular disease (CVD) with that of non-depressed normal comparison subjects using magnetic resonance imaging (MRI).
Methods£ºAltogether, 47 subjects were finally recruited from the Memory impairment clinics of Pusan National University Hospital in Korea. All subjects (late life major depression patients without CVD : n=21, matched non-depressed normal comparison subjects : n=26) underwent 3-tesla MRI.
Results£ºLate life major depression patients without CVD showed reduced cortical thickness in left precuneus, left inferior temporal gyrus, and left cuneus compared with non-depressed normal comparison subjects.
Conclusion£ºOur findings suggest that late life major depression without CVD is associated with reduced cortical thickness.
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KEYWORD
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Late life major depression, Cortical thickness, Magnetic resonance imaging
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